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Palifosfamide

CAS號	31645-39-3
規(guī)格	5mg10mg	純度	98%
貨號	HY-14798	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規(guī)格	5mg10mg
純度	98%
貨號	HY-14798
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯(lián)系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥2325.00 元/5mg

立即詢盤

貨號	品牌	純度	規(guī)格	參考價	貨期
HY-14798	Medchemexpress	98%	5mg10mg	￥2325.00元/5mg	3天

產品詳情

詳細信息(中文)：
Palifosfamide (ZIO-201)是ifosfamide (IFOS)的活性代謝物，為DNA烷化劑，可作用于軟組織肉瘤（STS）。

詳細信息(英文)：
產品描述：PalifosfamidePalifosfamide (ZIO-201) is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS). _x000D_ IC50 Value: 0.5-1.5mg/ml [1]_x000D_ Target: DNA alkylator_x000D_ in vitro: Palifosfamide lysine was cytotoxic against all the cell lines tested with the IC(50) ranging from 0.5 to 1.5 microg/ml except for OS222, which had an IC(50) of 7 microg/ml [1]._x000D_ in vivo: Dose response, route and schedule of administration, and interaction with docetaxel or doxorubicin were investigated in NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts. Oral activity was investigated in P388-1 leukemia in CD2F1 mice. Oral and intraperitoneal bioavailabilities were compared in Sprague-Dawley rats. Stabilized palifosfamide administered by optimized regimens suppressed MX-1 tumor growth (P