上海中醫(yī)藥大學(xué)“活性小分子生物合成與中醫(yī)藥研究中心”博士研究生、博士后招生
上海中醫(yī)藥大學(xué)是中國領(lǐng)先的中醫(yī)藥高等教育和研究機(jī)構(gòu)之一。學(xué)校設(shè)有14個學(xué)院和9所附屬醫(yī)院。
“活性小分子生物合成與中醫(yī)藥研究中心”是一個新成立的國際化研究中心，專注于具有潛在生物活性的天然產(chǎn)物全合成以及其在藥物中的應(yīng)用。
申請者將參與萜類、生物堿類或肽類天然產(chǎn)物的全合成工作，或從事旨在促進(jìn)這類天然產(chǎn)物合成的新方法學(xué)開發(fā)。研究項(xiàng)目主要聚焦于具有顯著生物活性的天然產(chǎn)物，及其藥用潛力（如類似物設(shè)計、結(jié)構(gòu)–活性關(guān)系研究、臨床前研究）及相關(guān)的生物學(xué)研究（如化學(xué)蛋白質(zhì)組學(xué)、靶點(diǎn)驗(yàn)證等）。
學(xué)生將參與萜類、生物堿類或肽類等具有顯著生物活性的天然產(chǎn)物的全合成研究。
“活性小分子生物合成與中醫(yī)藥研究中心”是一個中德合作項(xiàng)目，特別注重海外研究人員和教師的融合。研究中心于2025年在塔尼亞-蓋奇教授和法比安-施耐德教授的領(lǐng)導(dǎo)下成立，現(xiàn)有總共6位成員。研究中心總面積接近1700平方米，資金充足，配備了全新的、現(xiàn)代化的合成與生物學(xué)實(shí)驗(yàn)室。其綜合分析設(shè)施包括600 MHz和400 MHz NMR譜儀（配備冷探頭）、高分辨率質(zhì)譜（HRMS）、液相色譜質(zhì)譜（LCMS）、手性HPLC、分析性與制備性HPLC，以及自動化中壓色譜系統(tǒng)等。
我們計劃招募多名博士研究生（4-5名），博士后研究人員（4-5名）。對于特別優(yōu)秀的博士及博士后將有機(jī)會前往德國知名高校交流、深造。
法比安-施耐德 教授
Fabian Schneider 于2021年在康斯坦茨大學(xué)獲得有機(jī)合成博士學(xué)位。之后，他在Scripps研究所與Phil Baran教授合作進(jìn)行博士后研究，并于2025年開始加入上海中醫(yī)藥大學(xué)“活性小分子生物合成與中醫(yī)藥研究中心”開展獨(dú)立研究工作，專注于萜類、生物堿和肽類天然產(chǎn)物的全合成研究。他獲得了包括天然產(chǎn)物化學(xué)研究的DECHEMA獎以及由亞歷山大·馮·洪堡基金會資助的Feodor-Lynen獎學(xué)金等多個獎項(xiàng)。目前為止在Science、Nature、JACS,等國際著名期刊 上發(fā)表論文多篇。
申請者應(yīng)具備基本的有機(jī)化學(xué)基礎(chǔ)知識并能夠?qū)⑵鋺?yīng)用于合成問題，化學(xué)或者藥學(xué)相關(guān)專業(yè)均可
申請者還應(yīng)具有濃厚的有機(jī)合成和藥物研發(fā)興趣，并對研究工作充滿熱情。
●Pan L.,? Schneider F.,? Ottenbruch M., Wiechert R., List T., Schoch P.,Mertes B., Gaich T., A general strategy for the synthesis of taxane diterpenes, Nature 2024, 632, 543–549.
●Schneider F., Samarin K., Zanella S., Gaich T., Total synthesis of the complex taxane diterpene canataxpropellane, Science 2020, 367, 676-681.
●PSchneider F.,?Guo Y.,?Lin Y.-C.,?Eberle K. J., Chiodi D., Greene J. A., Lu C., Baran P. S., Total Synthesis of Dynobactin A, J. Am. Chem. Soc. 2024, 146, 6444-6448.
上海中醫(yī)藥大學(xué)將根據(jù)相關(guān)政策，為博士研究生和博士后提供有競爭力的薪資及補(bǔ)貼，具體待遇面議。
有意申請上海中醫(yī)藥大學(xué)“活性小分子生物合成與中醫(yī)藥研究中心”博士研究生及博士后可聯(lián)系以下教授：（申請材料可以使用中文或英文撰寫）
· 法比安-施耐德 (fschneider@scripps.edu, 微信: SchneiderF)
· 潘璐 （lu.pan@uni-konstanz.de, 微信：panlu_666）
Position offered: PhD and Postdoctoral Recruitment – Research Center for Bioactive Small Molecule Synthesis and Chinese Medicine, Shanghai University of Chinese Medicine
Description:
The Center for (bio)-synthesis of active small molecules in Chinese Medicine’ is a recently established research center focused on organic synthesis with a special focus on the total synthesis of natural products and exploration of their potential for medicinal applications.
Students will work on the total synthesis of terpene, alkaloid or peptide based natural products or methodology projects specifically aimed at facilitating synthetic access to these classes of natural products. Projects are specifically targeting natural products with potent biological application, aiming to subsequently enable further exploration of their medicinal potential (e.g. analogue generation, structure activity relationship, further preclinical studies) or biological investigation (e.g. chemoproteomics studies, target validation) in cooperation with partners of the research center.
The ‘Center for (bio)-synthesis of active small molecules in Chinese Medicine’ is a Chinese-German cooperation with a special emphasis on the integration of overseas researchers and faculty. Founded in 2025 under the tutelage of Prof. Fabian Schneider. The research center includes currently 6 faculty members with a highly successful record track in the field of organic synthesis. The research center spans nearly 1,700 square meters, is well-funded, and boasts brand-new, fully equipped state-of-the-art synthetic and biological laboratories. Its comprehensive analytical infrastructure includes 600 MHz and 400 MHz NMR spectrometers with cryoprobes, HRMS, LCMS, chiral HPLC, analytical and preparative HPLC, as well as automated medium-pressure chromatography systems.
The research center is located at the Shanghai University of Chinese Medicine which enables access to it’s 9 affiliated hospitals. In addition to it’s university labs, the research center is also present at the Longhua hospital which enables access to advanced biological research facilities and enables translational medicine studies.
We plan to recruit multiple PhD students (4–5) and postdoctoral researchers (4–5). Outstanding candidates will have the opportunity to conduct collaborative research or pursue further training at leading universities in Germany.
Prof. Fabian Schneider (ORCID 0000-0001-6651-1127)
Fabian Schneider graduated with a PhD in organic synthesis from the University of Konstanz in 2021. After postdoctoral studies with Prof. Phil Baran at Scripps research in La Jolla, CA, USA he started his independent career 2025 at the Center for (bio)-synthesis of active small molecules in Chinese Medicine where he is currently holding a position as chair professor, focused on research in the total synthesis of terpene and peptide natural products. He received among others the DECHEMA Award for research in natural products chemistry and support by a Feodor-Lynen Fellowship by the Alexander von Humboldt Foundation. To date, he has published multiple papers in internationally renowned journals such as Science, Nature, and JACS.
Representative Faculty Publications (selection):
●Pan L.,? Schneider F.,? Ottenbruch M., Wiechert R., List T., Schoch P.,Mertes B., Gaich T., A general strategy for the synthesis of taxane diterpenes,Nature 2024, 632, 543–549.
●Schneider F., Samarin K., Zanella S., Gaich T., Total synthesis of the complex taxane diterpene canataxpropellane, Science 2020, 367, 676-681.
●Schneider F.,? Guo Y.,? Lin Y.-C.,? Eberle K. J., Chiodi D., Greene J. A., Lu C., Baran P. S., Total Synthesis of Dynobactin A, J. Am. Chem. Soc. 2024, 146, 6444-6448.
Benefits:
Shanghai University of Traditional Chinese Medicine will provide competitive salaries and stipends for PhD students and postdoctoral researchers in accordance with relevant university policies. Specific compensation details will be discussed during the interview process.
Requirements:
Applicants should have a strong interest in organic synthesis and a genuine passion for research A solid foundation in organic chemistry and the ability to apply their knowledge to typical synthetic problems is advantageous.. Applications can be written in either Chinese or English.
Application:
Prospective PhD students and postdoctoral researchers interested in joining the “Research Center for Bioactive Small Molecule Synthesis and Traditional Chinese Medicine” at Shanghai University of Traditional Chinese Medicine are encouraged to contact the following professors:
· Fabian Schneider (fschneider@scripps.edu, WeChat: SchneiderF)
· Lu Pan （lu.pan@uni-konstanz.de, WeChat: panlu_666）
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